Lv11
36 积分 2021-06-07 加入
Multivalent mannose-conjugated siRNA causes robust gene silencing in pancreatic macrophages in vivo
5小时前
已完结
Ex vivo machine perfusion enables robust and widespread lipophilic-conjugated siRNA delivery to the porcine lung
4天前
已完结
An siRNA targeting S6k1 identifies photoreceptor phospholipid metabolism as a contributor to lipid buildup in age-related macular degeneration
12天前
已关闭
Cell-penetrating asymmetric siRNA targeting MyD88 suppresses inflammasome-driven ocular degeneration and angiogenesis
13天前
已完结
Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides
1个月前
已完结
Hydrogen Fluoride Imidazole: A Simple, Efficient, Mild, and Cost-Effective Silyl-Ether Deprotection Reagent
2个月前
已完结
Novel and Practical Synthesis of Triantennary N-Acetylgalactosamine Ligands for Liver-Targeted Delivery of siRNA Therapeutics
2个月前
已完结
Facile Synthesis, Geometry, and 2′-Substituent-Dependent in Vivo Activity of 5′-(E)- and 5′-(Z)-Vinylphosphonate-Modified siRNA Conjugates
3个月前
已完结
Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides
3个月前
已完结
Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3′ End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain
4个月前
已完结
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