Lv1
16 积分 2021-06-07 加入
Facile Synthesis, Geometry, and 2′-Substituent-Dependent in Vivo Activity of 5′-(E)- and 5′-(Z)-Vinylphosphonate-Modified siRNA Conjugates
23小时前
已完结
Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides
20天前
已完结
Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3′ End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain
1个月前
已完结
Attachment of Nucleosides and Other Linkers to Solid‐Phase Supports for Oligonucleotide Synthesis
1个月前
已完结
A Universal and Recyclable Solid Support for Oligonucleotide Synthesis
1个月前
已完结
Impact of Phosphorothioate Chirality on Double‐Stranded siRNAs: A Systematic Evaluation of Stereopure siRNA Designs
2个月前
已完结
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates
2个月前
已完结
Synthesis of Phosphorodithioate DNA via Sulfur-Linked, Base-Labile Protecting Groups1
3个月前
已完结
Unlocking biological barriers: nonclinical safety considerations for RNA-based complex biologics
3个月前
已完结
Preclinical evaluation of 68Ga-labeled acetazolamide derivatives as radiotracers targeting carbonic anhydrase IX in clear cell renal cell carcinoma
3个月前
已完结
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