Lv11
30 积分 2025-06-29 加入
A Novel CSN5 Inhibitor Drives Tumor-Intrinsic PD-L1 Degradation and Exerts Direct Antitumor Efficacy in Triple-Negative Breast Cancer
6小时前
待确认
A Rationally Designed Novel Bifunctional Human TNF-α- and Janus Kinase-Targeted soloMER Drug Conjugate (SDC) with a Neutrophil Elastase Cleavable Linker Delivering Inflammation Site-Specific Release of Payload
2个月前
已完结
Enantioselective Total Synthesis of (+)-Subincanadine F via Organo-SOMO Catalysis
2个月前
已完结
Bifunctional Monothiosquaramide-Catalyzed Enantioselective Addition of Masked Acyl Cyanide to Isatins: Umpolung Strategy for the Total Synthesis of (S)()-Dioxibrassinin and (R)(+)-Spirobrassinin
2个月前
已关闭
First-in-Class Quinoline-Dione-Derived PROTACs: Potent Degraders of Cdc25 Phosphatases for Antitumor Therapy
2个月前
已完结
A Bispecific Peptide–Drug Conjugate Targeting LAG-3 and PD-L1 Harnesses Antitumor Immunity of Macrophages and T Cells
2个月前
已完结
Total Synthesis of (±)‐Cristaxenicin A: Construction of Nine‐Membered Ring by Eschenmoser–Claisen/Cope Rearrangement Cascade
2个月前
已完结
CSN5 overexpression promotes the integral progression of cervical cancer by enhancing ENO3-mediated glycolysis
4个月前
已完结
CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome
4个月前
已完结
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