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42 积分 2025-06-09 加入
The reactivity-driven biochemical mechanism of covalent KRASG12C inhibitors
30天前
已完结
Gamma secretase modulators and BACE inhibitors reduce Aβ production without altering gene expression in Alzheimer's disease iPSC-derived neurons and mice
1个月前
已完结
Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease
1个月前
已完结
Safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel γ-secretase modulator, E2212, in healthy human subjects
1个月前
已完结
Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease
1个月前
已完结
Investigational BACE inhibitors for the treatment of Alzheimer’s disease
1个月前
已完结
Pre-dementia clinical stages in presenilin 1 E280A familial early-onset Alzheimer's disease: a retrospective cohort study
1个月前
已完结
Fitting of kinact and KI Values from Endpoint Pre-incubation IC50 Data
1个月前
已完结
Discovery of Potent and Highly Selective Interleukin-2-Inducible T-Cell Kinase Degraders with In Vivo Activity
1个月前
已完结
DMPK Considerations for the Development of Covalent Drugs: Insights from an IQ Assessment
2个月前
已完结
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