Lv61
2030 积分 2026-01-23 加入
Discovery of potent, selective, and orally bioavailable monocyclic pyridine-based PKMYT1 inhibitors that synergize with CHK1 inhibition in replication-stressed cancer cells
8天前
已完结
Pyridazino-Indoles as Phenol Bioisosteres for Potent Inhibition of NLRP3
9天前
已完结
Discovery and In Vitro Characterization of Macrocyclic 2-(Heteroaryl)Pyrimidine Inhibitors Targeting Wild-Type KRAS and G12D/G12V Mutants
9天前
已完结
Tertiary Alcohol: Reaping the Benefits but Minimizing the Drawbacks of Hydroxy Groups in Drug Discovery
14天前
已完结
Discovery of Fluoroalkenes as Dual Inhibitors of Diacylglycerol Kinases Alpha and Zeta (DGKα/ζ)
14天前
已完结
Soft drugs: design principles and topical applications
22天前
已完结
The story of amylin: from physiology to therapy
22天前
已完结
Exploiting Bridged Conformations for Precise Molecular Recognition in the Design of KRAS-Selective, Orally Available Macrocyclic Peptides
24天前
已完结
Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor
24天前
已完结
Brain-shuttle biologics chart new paths across the blood–brain barrier
25天前
已完结
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