Lv6
1930 积分 2022-07-09 加入
Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces and prevents pain chronification in a mouse model of oxaliplatin-induced neuropathic pain
3天前
已关闭
Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels
3天前
已完结
A Multifunctional Radiotheranostic Agent for Dual Targeting of Breast Cancer Cells
17天前
已完结
Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases
19天前
已完结
Copper-Catalyzed Enantioselective Three-Component Synthesis of Optically Active Propargylamines from Aldehydes, Amines, and Aliphatic Alkynes
1个月前
已完结
Nickel-Catalyzed C−I-Selective C(sp2)−C(sp3) Cross-Electrophile Coupling of Bromo(iodo)arenes with Alkyl Bromides
1个月前
已完结
Rhodium-Catalyzed Asymmetric [5+2] Cycloaddition of Alkyne–Vinylcyclopropanes
1个月前
已完结
Rational Design of Potent and Orally Efficacious PI3Kα/δ Degrader for PIK3CA Mutant Breast Cancer without Hyperglycemic Liability
2个月前
已完结
Discovery of Potent and Selective Imidazo[2,1-b][1,3,4]thiadiazole-Based MNK1/2 Inhibitors with Significant Efficacy against Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease
2个月前
已完结
Structure-Based Rational Design and Evaluation of BET-Aurora Kinase Dual-Inhibitors for Treatment of Cancers
3个月前
已完结
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