Lv3
280 积分 2024-08-16 加入
Structure-Based Discovery of Quinazolin-2-amine Derivatives as Potent ROR1 Pseudokinase Inhibitors with In Vitro and In Vivo Efficacy against Triple-Negative Breast Cancer
8小时前
待确认
Targeting WRN helicase: Discovery and development of its selective inhibitors
13天前
已完结
WRN as a Novel Target of Synthetic Lethality: Current Advances and Future Perspectives
13天前
已完结
Small Molecules Targeting the Transmembrane Domain
15天前
已完结
Radioactive ADME Demonstrates ARV-110’s High Druggability Despite Low Oral Bioavailability
2个月前
已完结
Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli
2个月前
已完结
Synthesis and Evaluation of Novel C-X-C Chemokine Receptor 4-Targeted Radiotracers for Oncological Imaging
3个月前
已完结
A neomorphic protein interface catalyzes covalent inhibition of RAS G12D aspartic acid in tumors
4个月前
已完结
Development of a Selective and Potent PRMT4 PROTAC Degrader with Efficacy against Multiple Myeloma in Vitro and in Vivo
4个月前
已完结
Discovery of KIN-8741, a Highly Selective Type IIb c-Met Kinase Inhibitor with Broad Mutation Coverage and Quality Drug-Like Properties for the Treatment of Cancer
5个月前
已完结
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