Lv526
820 积分 2024-09-14 加入
A Shift in Thinking: Cellular Thermal Shift Assay-Enabled Drug Discovery
22小时前
已完结
Development of 9H-purine scaffold as novel CDK2 inhibitors: Design, synthesis, and biological evaluation
5天前
已完结
Identification of Potent CDK9 Inhibitors with Novel Skeletons via Virtual Screening, Biological Evaluation, and Molecular Dynamics Simulation
6天前
已完结
Targeting Cyclin-Dependent Kinases: From Pocket Specificity to Drug Selectivity
6天前
已完结
Discovery of Selective Tertiary Amide Inhibitors of Cyclin-Dependent Kinase 2 (CDK2)
6天前
已完结
Discovery of a Novel Dihydroisoquinolinone Derivative as a Potent CDK9 Inhibitor Capable of Overcoming L156F Mutant for the Treatment of Hematologic Malignancies
8天前
已完结
Bicyclo[m.n.k]alkane Building Blocks as Promising Benzene and Cycloalkane Isosteres: Multigram Synthesis, Physicochemical and Structural Characterization
12天前
已完结
Discovery and Optimization of Pyridazinones as PI3Kδ Selective Inhibitors for Administration by Inhalation
12天前
已完结
Toward Dual Targeting of Catalytic and Gatekeeper Pockets in Cyclophilins Using a Macrocyclic Scaffold
12天前
已完结
Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors
13天前
已完结
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