Lv11
70 积分 2025-05-28 加入
Discovery of novel pyridazine derivatives as glucose transporter type 4 (GLUT4) translocation activators
6小时前
待确认
Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin
8小时前
已完结
Overcoming E3 Ligase-Mediated Resistance: Development of Novel Hydrophobic Tagging-Based Degraders Targeting ALK Protein
3天前
已完结
NDA Submission of Vepdegestrant (ARV-471) to U.S. FDA: The Beginning of a New Era of PROTAC Degraders
3天前
已完结
A small-molecule VHL molecular glue degrader for cysteine dioxygenase 1
3天前
已完结
Practical perspectives on addressing hepatotoxicity during clinical candidate selection
7天前
已完结
Correction to “Closing the Design–Make–Test–Analyze Loop: Interplay between Experiments and Predictions Drives PROTACs Bioavailability”
7天前
已完结
Selective degradation of BRD9 by a DCAF16-recruiting targeted glue: mode of action elucidation and in vivo proof of concept
10天前
已关闭
Finding a needle in the haystack: ADME and pharmacokinetics/pharmacodynamics characterization and optimization toward orally available bifunctional protein degraders
12天前
已完结
EGFR degraders in non‐small‐cell lung cancer: Breakthrough and unresolved issue
13天前
已完结
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