Lv6
1830 积分 2022-01-04 加入
Systematic Evaluation of Maleimide Spacer Impact on Drug-Linker Deconjugation in Antibody-Drug Conjugates Ex Vivo and In Vivo
9小时前
已完结
Structural optimization elaborates novel potent Akt inhibitors with promising anticancer activity
4天前
已完结
From Lead to Clinical Candidate: Discovery of BMS-986331 as a Potent and Selective N -Formyl Peptide Receptor 2 Agonist
8天前
已完结
Synthesis and biological activities of tetrahydroquinazoline analogs of aminopterin and methotrexate
12天前
已完结
Exploitation of the Ability of γ-Tocopherol to Facilitate Membrane Co-localization of Akt and PHLPP1 to Develop PHLPP1-Targeted Akt Inhibitors
14天前
已完结
Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells
14天前
已完结
Akt Inhibitor Advancements: From Capivasertib Approval to Covalent-Allosteric Promises
14天前
已完结
Discovery of Potent and Brain-Penetrant Inverse Agonists for GPR61, an Orphan G Protein-Coupled Receptor
15天前
已完结
Discovery of Potent and Brain-Penetrant Inverse Agonists for GPR61, an Orphan G Protein-Coupled Receptor
21天前
已完结
Discovery of a Novel Phenyl Thiophene-3-carboxamide Derivative DZX19 as an Orally TRK Inhibitor with Potent Antitumor Effects
22天前
已完结
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