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28 积分 2023-11-27 加入
An AI-Driven Chemogenomics Knowledgebase for Human-Transmissible Pathogens: A Platform for Antimicrobial Drug Discovery
2天前
已完结
Advances in Small-molecule Dual Inhibitors Targeting EGFR and HER2 Receptors as Anti-cancer Agents
3天前
已完结
An AI-Driven Chemogenomics Knowledgebase for Human-Transmissible Pathogens: A Platform for Antimicrobial Drug Discovery
4天前
已完结
Discovery of Amodiachins, a Novel Class of 4-Aminoquinoline Antimalarials Active against Multidrug-Resistant Plasmodium falciparum
4天前
已完结
Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity
5天前
已完结
Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119
7天前
已完结
NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation
9天前
已完结
Identification of two repurposed drugs targeting GSDMD oligomerization interface I to block pyroptosis
10天前
已完结
Novel GSDMD inhibitor GI-Y1 attenuates sepsis-induced myocardial dysfunction by targeting Gasdermin D and inhibiting Gasdermin D-mediated pyroptosis
14天前
已完结
Gasdermin D (GSDMD) as a new target for the treatment of infection
14天前
已完结
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