Lv1
40 积分 2026-07-24 加入
Design, synthesis and structure–activity relationship of indolylindazoles as potent and selective covalent inhibitors of interleukin-2 inducible T-cell kinase (ITK)
20小时前
待确认
Development of Potent and Selective EGFR-PROTACs Based on Macrocyclic Fourth-Generation EGFR Inhibitors
7天前
已完结
Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo
14天前
已完结
Property- and Structure-Guided Discovery of a Tetrahydroindazole Series of Interleukin-2 Inducible T-Cell Kinase Inhibitors
14天前
已完结
Discovery of Novel Bruton’s Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy
15天前
已完结
X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase
28天前
已完结
Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors
1个月前
已完结
A Role for Hydration in Interleukin‐2 Inducible T Cell Kinase (Itk) Selectivity
1个月前
已完结
Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis
1个月前
已完结
Discovery of pyrazole-based selective covalent ITK inhibitors with In vivo activity
1个月前
已完结
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