Lv1
10 积分 2023-03-08 加入
Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation
3天前
已完结
Ligands for cereblon: 2017–2021 patent overview
3天前
已完结
Targeted Degradation of the Wiz Transcription Factor for Gamma Globin De-Repression
9天前
已完结
Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease
11天前
已完结
CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers
11天前
已完结
Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases
11天前
已完结
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
18天前
已完结
TBN-triggered, manipulable annulations of o-hydroxyarylenaminones for divergent syntheses of oximinochromanones and oximinocoumaranones
22天前
已完结
A Case Study on the Impact of Thermal Hydrolysis and Lactone Ring Opening of Linker-Payload on Drug-to-Antibody Ratio Determination in a Topoisomerase I Inhibitor-Based ADC
23天前
已完结
Drug Delivery Strategy Exploiting Amino Acid Prodrugs: Improving Oral Bioavailability and Overcoming Nonlinear Pharmacokinetic Challenges Following Dose Escalation of a CK2 Inhibitor with Poor Solubility
24天前
已完结
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