Lv1
30 积分 2023-03-08 加入
Discovery of Novel N-Linked Camptothecin Linker-Payloads to Access Antibody-Drug Conjugates with High Target-Mediated In Vivo Efficacy
7天前
已完结
Design of Novel Exatecan-Amide Linker-Payloads for the Development of Stable, Low-Aggregating, and Highly Efficacious Antibody-Drug Conjugates
7天前
已完结
Evaluation of Cereblon-Directing Warheads for the Development of Orally Bioavailable PROTACs
14天前
已完结
Systematic Evaluation of Maleimide Spacer Impact on Drug-Linker Deconjugation in Antibody-Drug Conjugates Ex Vivo and In Vivo
22天前
已完结
Discovery of Gut-Restricted PRMT5 Inhibitors to Intercept Colorectal Cancer in Patients with Genetic Loss of Tumor Suppressor Adenomatous Polyposis Coli
1个月前
已完结
Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson’s Disease
1个月前
已完结
Effect of Conjugation Site and Technique on the Stability and Pharmacokinetics of Antibody-Drug Conjugates
2个月前
已完结
Risk‐Based Pharmacokinetic and Drug–Drug Interaction Characterization of Antibody–Drug Conjugates in Oncology Clinical Development: An International Consortium for Innovation and Quality in Pharmaceutical Development Perspective
2个月前
已完结
Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12C
2个月前
已完结
Approaches to improve the translation of safety, pharmacokinetics and therapeutic index of ADCs
2个月前
已完结
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