Lv21
160 积分 2024-09-23 加入
An Alternative Synthetic Route to Rilzabrutinib via an E-Configured Cyanoacrylic Acid Intermediate
5小时前
已完结
Discovery ofHighly Potent and Selective, Orally BioavailableBTK-Targeting PROTACs Featuring Novel CRBN-Binding Warheads
7天前
已完结
Discovery of AK-1690: A Potent and Highly Selective STAT6 PROTAC Degrader
10天前
已完结
Overcoming AlbD Protease Resistance and Improving Potency: Synthesis and Bioactivity of Antibacterial Albicidin Analogues with Amide Bond Isosteres
11天前
已完结
Pharmacological Targeting of IRF4 As a Therapeutic Strategy for Multiple Myeloma
11天前
已完结
Structure-Based Design and Optimization of Onradivir-Derived PB2 Inhibitors for the Treatment of Influenza A
11天前
已完结
Asymmetric Synthesis of Monofluorinated Carbocyclic Alcohols and Vicinal Difluorinated Heterocycles and Carbocycles
12天前
已完结
Optimization of a Second-Generation, Highly Selective Polθ/PARP1 Dual Inhibitor with Improved Pharmacokinetics and Potent Activity against HR-Deficient Tumors
13天前
已完结
Discovery and Characterization of RP04340 : A Highly Potent and Orally Active Pan-KRAS PROTAC Degrader
14天前
已完结
Late-stage functionalization with strain-release warheads enables tunable covalent inhibition
1个月前
已完结
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