Lv42
580 积分 2021-06-24 加入
Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors
2小时前
已完结
Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics
2小时前
已完结
Discovery of Selective and Orally Bioavailable Heterobifunctional Degraders of Cyclin-Dependent Kinase 2
11天前
已完结
Abstract 4199: Inhibition of NF-kB inducing kinase (NIK) selectively abrogates NIK and TRAF3 mutant multiple myeloma tumor growth
1个月前
已关闭
The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site
1个月前
已完结
Inhibiting NF-κB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structure–activity relationship, and co-crystal structures
1个月前
已完结
Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation
1个月前
已完结
Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design
1个月前
已完结
Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase
1个月前
已完结
Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K)
1个月前
已完结
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