Lv31
360 积分 2021-06-24 加入
AI-Driven De Novo Design and Development of Nontoxic DYRK1A Inhibitors
2小时前
已完结
Discovery of Novel SIK2/3 Inhibitors for the Potential Treatment of MEF2C+ Acute Myeloid Leukemia (AML)
7天前
已完结
Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology
9天前
已完结
Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing
9天前
已完结
Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood
9天前
已完结
Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma
10天前
已完结
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors
10天前
已完结
Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13
10天前
已完结
The Promise and Current Status of CDK12/13 Inhibition for the Treatment of Cancer
10天前
已完结
Discovery of a Potent, Selective, and Brain-Penetrant Checkpoint Kinase 1 Inhibitor, BEN-28010, for the Treatment of Glioblastoma
10天前
已完结
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