Lv21
120 积分 2025-05-27 加入
Design, Synthesis, and Pharmacological Evaluation of Multisubstituted Pyrido[4,3-d]pyrimidine Analogues Bearing Deuterated Methylene Linkers as Potent KRASG12D Inhibitors
17天前
已完结
Overcoming a Radical Polarity Mismatch in Strain‐Release Pentafluorosulfanylation of [1.1.0]Bicyclobutanes: An Entryway to Sulfone‐ and Carbonyl‐Containing SF5‐Cyclobutanes
1个月前
已完结
Overall Survival with Inavolisib in PIK3CA -Mutated Advanced Breast Cancer
1个月前
已完结
Targeting RAS and PI3K in lung cancer
1个月前
已完结
Covalent inhibitors of the RAS binding domain of PI3Ka impair tumor growth driven by RAS and HER2
1个月前
已完结
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα
1个月前
已完结
BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction
2个月前
已完结
Myristoylation Confers Oral Bioavailability and Improves the Bioactivity of c(MyD 4–4), a Cyclic Peptide Inhibitor of MyD88
2个月前
已完结
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