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2780 积分 2024-01-07 加入
Reactive Oxygen Species-Instructed Supramolecular Assemblies Enable Bioorthogonally Activatable Protein Degradation for Pancreatic Cancer
9天前
已完结
GLUTs-Facilitated Targeting BRD4 Degradation in Breast Cancer through Carbohydrate-Conjugated PROTACs
9天前
已完结
Discovery of highly potent and selective KRASG12C degraders by VHL-recruiting PROTACs for the treatment of tumors with KRASG12C-Mutation
17天前
已完结
Lead Optimization of Multimutant KRAS Switch-II Pocket Macrocyclic Inhibitors via Isosteric Replacement to Improve ADME and Oral Exposure
20天前
已完结
Discovery of BMS-986458, a Potent and Selective B-Cell Lymphoma 6 Protein Ligand-Directed Degrader, for the Treatment of B-Cell Non-Hodgkin Lymphoma
25天前
已完结
Allosteric PROTACs: Expanding the Horizon of Targeted Protein Degradation
27天前
已完结
Chemistries of bifunctional PROTAC degraders
27天前
已完结
Proteolysis-targeting chimera (PROTAC) delivery system: advancing protein degraders towards clinical translation
27天前
已完结
Induced proximity-based therapeutic modalities
27天前
已完结
Dynamic characteristics of proteolysis-targeting chimera systems revealed by in silico computations
27天前
已完结
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