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36 积分 2025-10-11 加入
Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia
1天前
已完结
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo
1天前
已完结
Epigenetic reader SP140 loss of function drives Crohn’s disease due to uncontrolled macrophage topoisomerases
1天前
已完结
Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1
2天前
已完结
Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants
3天前
已完结
Sterical Hindrance Promotes Selectivity of the Autophagy Cargo Receptor NDP52 for the Danger Receptor Galectin-8 in Antibacterial Autophagy
7天前
已完结
Halogen–Aromatic π Interactions Modulate Inhibitor Residence Times
7天前
已完结
Diabetes Mellitus due to Misfolding of a β-Cell Transcription Factor: Stereospecific Frustration of a Schellman Motif in HNF-1α
9天前
已完结
Discovery of Novel 1-Phenylpiperidine Urea-Containing Derivatives Inhibiting β-Catenin/BCL9 Interaction and Exerting Antitumor Efficacy through the Activation of Antigen Presentation of cDC1 Cells
1个月前
已完结
Rational Design and Synthesis of Methyl-β-d-galactomalonyl Phenyl Esters as Potent Galectin-8N Antagonists
2个月前
已完结
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