Lv75
4848 积分 2021-07-08 加入
Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation
16天前
已完结
Advancing Strategies for Proteolysis-Targeting Chimera Design
16天前
已完结
Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRASG12D
16天前
已完结
Discovery of the First Potent, Selective, and In Vivo Efficacious Polo-like Kinase 4 Proteolysis Targeting Chimera Degrader for the Treatment of TRIM37-Amplified Breast Cancer
16天前
已完结
Discovery of Novel Bruton’s Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy
16天前
已完结
PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models
16天前
已完结
A Potent SOS1 PROTAC Degrader with Synergistic Efficacy in Combination with KRASG12C Inhibitor
16天前
已完结
Discovery of Potent and Highly Selective Interleukin-2-Inducible T-Cell Kinase Degraders with In Vivo Activity
16天前
已完结
ARE-PROTACs Enable Co-degradation of an Nrf2–MafG Heterodimer
16天前
已完结
Discovery of a Novel Class of PROTACs as Potent and Selective Estrogen Receptor α Degraders to Overcome Endocrine-Resistant Breast Cancer In Vitro and In Vivo
16天前
已完结
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