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Lv7
4948 积分
2021-07-08 加入
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Design and Evaluation of a Novel Peptide–Drug Conjugate Covalently Targeting SARS-CoV-2 Papain-like Protease
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Why 90% of clinical drug development fails and how to improve it?
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Structure‒tissue exposure/selectivity relationship (STR) correlates with clinical efficacy/safety
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Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers
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Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712
1个月前
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Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839
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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease
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Discovery of BAY-390, a Selective CNS Penetrant Chemical Probe as Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonist
1个月前
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