Lv5
1138 积分 2024-06-12 加入
Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors
13天前
已完结
Development and evaluation of mitochondria-targeted caseinolytic protease (ClpP) agonist chemical probes in in vitro breast cancer models
3个月前
已完结
A first-in-class oral clinical candidate targeting MLLT1 and 3 degradation for the treatment of advanced AML and ALL including menin inhibitor resistant / refractory disease
6个月前
已关闭
In Vitro Cytotoxicity Determination: Avoiding Pitfalls
6个月前
已关闭
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS
6个月前
已完结
Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers
6个月前
已完结
A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader
6个月前
已关闭
Nerandomilast, a PDE4B inhibitor, alleviates silica‐induced lung inflammation and fibrosis by inhibition of NLRP3 inflammasome and TGF‐β/Smad signalling
8个月前
已完结
A neomorphic protein interface catalyzes covalent inhibition of RAS G12D aspartic acid in tumors
8个月前
已完结
HER2-Selective and Reversible Tyrosine Kinase Inhibitor Tucatinib Potentiates the Activity of T-DM1 in Preclinical Models of HER2-positive Breast Cancer
9个月前
已完结
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