Lv5
1260 积分 2025-02-18 加入
Design, synthesis and biological evaluation of novel osimertinib derivatives as reversible EGFR kinase inhibitors
2天前
已完结
Synthesis and antitumor activity of a novel class of covalent inhibitors of EGFR with 2-indolone backbone
2天前
已完结
Identification of osimertinib (AZD9291) as a lysine specific demethylase 1 inhibitor
5天前
已关闭
Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity
8天前
已完结
Discovery of a Novel EGFR PROTAC Degrader against C797S Resistance Mutation with Potent Antitumor Efficacy in NSCLC Treatment
20天前
已完结
Atractylenolide III Ameliorated Autophagy Dysfunction via Epidermal Growth Factor Receptor-Mammalian Target of Rapamycin Signals and Alleviated Silicosis Fibrosis in Mice
21天前
已完结
Discovery of a Novel EGFR PROTAC Degrader against C797S Resistance Mutation with Potent Antitumor Efficacy in NSCLC Treatment
21天前
已完结
High Vascular Delivery of EGF, but Low Receptor Binding Rate Is Observed in AsPC-1 Tumors as Compared to Normal Pancreas
22天前
已完结
Rhein sensitizes human pancreatic cancer cells to EGFR inhibitors by inhibiting STAT3 pathway
22天前
已完结
Discovery and biological evaluation of proteolysis targeting chimeras (PROTACs) as an EGFR degraders based on osimertinib and lenalidomide
27天前
已完结
Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: results from a phase 1b/2a randomised controlled study
19天前
已采纳
Facile surface-engineered polymeric absorbents for simultaneous adsorption and degradation of organic wastes
28天前
已采纳
A fluorescence-electrochemiluminescence dual-mode sensor based on a "switch" system for highly selective and sensitive K-ras gene detection
28天前
已采纳
Cu-based active sites supported on nitrogen-rich polymer derived porous carbon fibers as an oxygen reduction electrocatalyst for zinc-air batteries
28天前
已采纳
Reversal Multidrug Resistance and Biodistribution of Targeted Nanoparticles Tf-Peg-PLL-PLGA Combined with Daunorubicin and Tetrandrine in Tumor-Bearing Nude Mice
1个月前
已采纳
Toward citizen science in food chemistry: Nitrite detection in high-fat food by integrating solid-phase extraction and electromembrane extraction on a microfluidic paper-based sensor
2个月前
已采纳
Claudin-18 isoform 2-specific CAR T-cell therapy (satri-cel) versus treatment of physician's choice for previously treated advanced gastric or gastro-oesophageal junction cancer (CT041-ST-01): a randomised, open-label, phase 2 trial
2个月前
已采纳
Towards effective indirect radioisotope energy converters with bright and radiation hard scintillators of (Gd,Y)3Al2Ga3O12 family
2个月前
已采纳
Nitric Oxide‐Releasing Nanoscale Metal‐Organic Layer Overcomes Hypoxia and Reactive Oxygen Species Diffusion Barriers to Enhance Cancer Radiotherapy
3个月前
已驳回
微波辅助提取葡萄渣中花青素的工艺研究
3个月前
已采纳
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