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538 积分 2025-02-10 加入
Kilogram-Scale Synthesis and Impurity Profiling of a COPD Candidate LY104: Optimization of Salt Forms for Enhanced Purity and Pharmaceutical Potential
3天前
已完结
WRN as a Novel Target of Synthetic Lethality: Current Advances and Future Perspectives
5天前
已完结
Development of Substituted Phenyl Dihydrouracil as the Novel Achiral Cereblon Ligands for Targeted Protein Degradation
6天前
已完结
A Concise Flow Synthesis of the IKZF2 Glue Degrader DKY709
7天前
已完结
Multigram-Scale Synthesis and Study of Reactivity of Two Difluoromethylating Reagents Based on Sulfoximine Skeletons
7天前
已完结
Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library Screen
10天前
已完结
In Vitro ADME Profiling of PROTACs: Successes, Challenges, and Lessons Learned from Analysis of Clinical PROTACs from a Diverse Physicochemical Space
13天前
已完结
Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library Screen
14天前
已完结
Discovery of a Potent and Selective GSPT1 Molecular Glue Degrader for the Treatment of Castration-Resistant Prostate Cancer
19天前
已完结
Discovery and Characterization of RP03707: A Highly Potent and Selective KRASG12D PROTAC
20天前
已完结
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