Lv43
484 积分 2024-01-29 加入
Old Wine in New Bottles? Deuterium Switch (Replacing Hydrogen With Deuterium) Comes to Thoracic Oncology as Deuterated Lorlatinib (Deulorlatinib, TGRX-326) and Deuterated Osimertinib (Asandeutertinib, TY-9591) in ALK+ NSCLC and EGFR+ NSCLC, Respectively
2小时前
已关闭
The MEK–RAF molecular glue IK-595 has potent antitumor activity across RAS/MAPK pathway-altered cancers
2天前
已完结
New perspectives for targeting therapy in ALK-positive human cancers
1个月前
已完结
Conformational Transition of Key Structural Features Involved in Activation of ALK Induced by Two Neuroblastoma Mutations and ATP Binding: Insight from Accelerated Molecular Dynamics Simulations
1个月前
已完结
Production of a genetically encoded biosensor for evaluating enterovirus 71 3C protease inhibitors
1个月前
已完结
ALKR1275Q perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN
1个月前
已完结
Foritinib, a type II ROS1 inhibitor for NSCLC
1个月前
已完结
Preclinical characterization and clinical trial of CFI-400945, a polo-like kinase 4 inhibitor, in patients with relapsed/refractory acute myeloid leukemia and higher-risk myelodysplastic neoplasms
1个月前
已完结
Design, synthesis, and biological evaluation of a potent PLK4 inhibitor WY29 with 1H‐pyrazolo[3,4‐d]pyrimidine scaffold
1个月前
已完结
Furo[2,3- f ]quinazolin-7(6 H )-one Derivatives as Potent, Selective, and Orally Bioavailable MAT2A Inhibitors for MTAP-Deficient Cancer Therapy
1个月前
已完结
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