Lv61
3028 积分 2024-08-15 加入
Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease
1个月前
已完结
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy
1个月前
已完结
Facile Conversion of Molecularly Complex (Hetero)aryl Carboxylic Acids into Alkynes for Accelerated SAR Exploration
1个月前
已完结
Desulfonylative Arylation of Redox-Active Alkyl Sulfones with Aryl Bromides
1个月前
已完结
Enantioselective Synthesis of a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 5 (mGluR5) Receptor via Dynamic Kinetic Resolution of α-Amino Ketones
1个月前
已完结
Enzymatic reduction of α-substituted ketones with concomitant dynamic kinetic resolution
1个月前
已完结
Engineering a Keto-Reductase for the Mass-Efficient Synthesis of a Key Building Block, Trans -Ethyl (3-Hydroxycyclobutyl)Acetate
2个月前
已完结
Versatile Construction of a 4-Substituted Piperidine by Continuous Preparation of a Complex Grignard and Addition to an In Situ Generated Pyridinium Species
2个月前
已完结
Development of a Fluoride Scavenging Strategy to Allow a S N Ar Reaction in a Glass-Lined Reactor toward the Synthesis of NBI-921352
2个月前
已完结
Differential Scanning Calorimetry Sees the Light: Simultaneous Photo-Irradiation and Temperature Ramping of Sealed DSC Crucibles for Thermal Assessment of Photochemical Processes
2个月前
已完结
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