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170 积分 2025-04-17 加入
Why next-generation mechanistic models will transform drug discovery: integrating efficacy and safety
2天前
已完结
Characterization of CYP3A5 Selective Inhibitors for Reaction Phenotyping of Drug Candidates
8天前
已完结
In vitro reversible enzyme inhibition assays to predict drug-drug interactions: Current state and industry perspective from the IQ Consortium Enzyme Inhibition Working Group
8天前
已完结
A framework for optimized reaction phenotyping of the seven major hepatic P450 isoforms in human liver microsomes using six mechanism-based inactivators and one reversible inhibitor
8天前
已关闭
An In Vitro Model for Predicting In Vivo Inhibition of Cytochrome P450 3A4 by Metabolic Intermediate Complex Formation
1个月前
已完结
Compatibility of Caco-2 cells with Simulated Intestinal Fluid-Predicting Permeability
2个月前
已关闭
Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants
2个月前
已完结
Improvement in static and dynamic projections of drug-drug interactions caused by cytochrome P4503A time-dependent inhibitors through in vitro allosteric modulation by progesterone
2个月前
已关闭
Quantitative Systems Toxicology Identifies Independent Mechanisms for Hepatotoxicity and Bilirubin Elevations Due to AKR1C3 Inhibitor BAY1128688
6个月前
已完结
Assessing Liver Effects of Cannabidiol and Valproate Alone and in Combination Using Quantitative Systems Toxicology
6个月前
已完结
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