Lv1
58 积分 2022-10-27 加入
Discovery of Pyrazole-Containing 4-Arylindolines as Potent Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction
1天前
待确认
Modified siRNAs for the study of the PAZ domain
1个月前
已完结
Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3′ End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain
1个月前
已完结
How to Computationally Stack the Deck for Hit-to-Lead Generation: In Silico Molecular Interaction Energy Profiling for de Novo siRNA Guide Strand Surrogate Selection
1个月前
已完结
Expanding the binding space of argonaute-2: incorporation of either E or Z isomers of 6′-vinylphosphonate at the 5′ end of the antisense strand improves RNAi activity
1个月前
已完结
Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance
1个月前
已关闭
Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model
2个月前
已关闭
Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors
2个月前
已完结
Virtual screening, molecular simulations and bioassays: Discovering novel microsomal prostaglandin E Synthase-1 (mPGES-1) inhibitors
2个月前
已完结
Structural insights into RNA cleavage by PIWI Argonaute
2个月前
已完结
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