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44 积分 2025-07-24 加入
Fragment-Based Discovery of an Oral Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine
6天前
已完结
Desensitization of CGRP and adrenomedullin receptors in SK-N-MC cells: implications for the RAMP hypothesis
7天前
已完结
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
7天前
已完结
Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): a Calcitonin Gene-Related Pepti
11天前
已完结
Expanding the GPCR-RAMP interactome
20天前
已完结
Multivitamin-mineral supplementation prevents acute upper respiratory tract infections
1个月前
已关闭
Structure-guided rational design of dual-target CGRP antagonist/5HT1F agonist therapeutics for migraine
1个月前
已完结
Synthesis and evaluation of neuroactive steroids with novel pharmacophore at C-21 let identify a compound with advantageous PK profile and higher EC50 and Emax as PAM on GABAA receptor
1个月前
已完结
Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success
4个月前
已完结
Discovery of (5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An Oral Calcitonin Gene-Related Peptide (CGRP) Antagonist in Clinical Trials for Treating Migraine
4个月前
已完结
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