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20 积分 2026-01-05 加入
A Type II CDK6 Degrader Enables Cellular Targeting beyond the Limits of Type II Inhibition
1个月前
已完结
Structure–Activity Relationships in a Series of Dihydrouracil-JQ1 Conjugates: Discovery of Highly Potent BRD4 Degraders
2个月前
已完结
Structure–Activity Relationships in a Series of Dihydrouracil-JQ1 Conjugates: Discovery of Highly Potent BRD4 Degraders
2个月前
已关闭
Discovery and Optimization of 4-Methylquinazoline Derivatives as Highly Selective PI3Kδ Inhibitors for the Treatment of Acute Lung Injury
2个月前
已完结
Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for Cancer Immunotherapy
2个月前
已完结
Structure–Activity Relationships in a Series of Dihydrouracil-JQ1 Conjugates: Discovery of Highly Potent BRD4 Degraders
2个月前
已关闭
Selectively Targeting the Kinome-Conserved Lysine of PI3Kδ as a General Approach to Covalent Kinase Inhibition
3个月前
已完结
Comprehensive Assessment and Benchmark of Deep Generative Models for Proteolysis TArgeting Chimera (PROTAC) Design
3个月前
已完结
Discovery of Novel Disubstituted l -Prolinamide Derivatives as Selective PI3Kα Inhibitors for Anticancer Therapy
5个月前
已完结
Lessons learned in linking PROTACs from discovery to the clinic
7个月前
已完结
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