Lv6
2658 积分 2020-07-27 加入
Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase
25天前
已完结
Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells
1个月前
已完结
Preclinical characterization of TGRX-678, a brain-penetrant allosteric inhibitor of BCR::ABL1
2个月前
已关闭
An MDM2 degrader for treatment of acute leukemias
3个月前
已完结
Tgrx-678, a Novel Allosteric Inhibitor of BCR-ABL1, Demonstrates Preclinical Anti-Leukemia Activity, High Oral Bioavailability and Synergism with Ponatinib to Suppress the Highly Resistant Compound Mutations
3个月前
已关闭
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
3个月前
已完结
Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis
3个月前
已完结
Targeting MDM2 in Soft-Tissue Sarcomas (and Other Solid Tumors): The Revival?
4个月前
已完结
Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression
4个月前
已完结
The Dawn of Allosteric BCR-ABL1 Drugs: From a Phenotypic Screening Hit to an Approved Drug
4个月前
已完结
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