Lv41
732 积分 2026-08-10 加入
A Frizzled‐Like Cysteine‐Rich Domain in Glypican‐3 Mediates Wnt Binding and Regulates Hepatocellular Carcinoma Tumor Growth in Mice
1个月前
已完结
Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor
1个月前
已完结
Derisking Affinity Optimization for Macrocycles and Cyclic Peptides: High-Precision Free Energy Simulations across Five Diverse Targets
1个月前
已完结
A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors
1个月前
已完结
Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning
1个月前
已完结
Structure‐based design of a T‐cell receptor leads to nearly 100‐fold improvement in binding affinity for pepMHC
1个月前
已完结
Structure–Activity Studies in a Family of β-Hairpin Protein Epitope Mimetic Inhibitors of the p53–HDM2 Protein–Protein Interaction
1个月前
已完结
Robust Prediction of Relative Binding Energies for Protein–Protein Complex Mutations Using Free Energy Perturbation Calculations
2个月前
已完结
Kinetics and Thermodynamics of Reversible Thiol Additions to Mono- and Diactivated Michael Acceptors: Implications for the Design of Drugs That Bind Covalently to Cysteines
2个月前
已完结
A chemigenetic endogenous Ras activity biosensor for live-cell pharmacology
2个月前
已完结
Self-Assembly of Single-Crystalline Nanomaterials for Integrated Electronics and Photonics
14天前
已采纳
Majority Rule of Enantiomeric Excess in Chiral Halide Perovskites for Continuous Tuning of Chiroptical Properties
14天前
已采纳
Subsoil versus Topsoil Straw Addition Shifts Microbial Carbon Allocation for Enhanced Carbon Sequestration and Emission Mitigation
14天前
已采纳
Synthesis and Characterization of Star-Shaped Poly(ethylene- c o -propylene) Polymers Bearing Terminal Self-Complementary Multiple Hydrogen-Bonding Sites
24天前
已采纳
Investigation of Pd leaching from supported Pd catalysts during the Heck reaction
24天前
已采纳
Combining Residue Substitution and Deletion Engineering Enhances the Substrate Acceptance of Ene-Reductase for Highly Enantioselective Synthesis of β‑Cyano Ester Scaffolds
24天前
已采纳
Design and Optimization of Lysosome-Targeted β‑Galactoside Senolytic Prodrugs: Harnessing the Aromatic Ring of Self-Immolative Linkers
24天前
已采纳
Third-Harmonic Generation in Crumpled Silicon Nanomembranes
24天前
已采纳
Regulation of target gene expression by chromatin-associated protein-coding transcripts in plants
30天前
已采纳
Regulation of target gene expression by chromatin-associated protein-coding transcripts in plants
30天前
已采纳
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