Lv4
668 积分 2021-04-09 加入
Strategic Design of Triple GLP-1R/GCGR/GIPR Agonists with Varied Receptor Potency: Achieving Comparable Glycemic and Weight Reduction Effects
13天前
已完结
Comprehensive computational modeling and interactions mechanisms of GIPR homodimerization
13天前
已关闭
Structure–Activity Relationship Guided Scaffold Hopping Resulted in the Identification of GLPG4970, a Highly Potent Dual SIK2/SIK3 Inhibitor
17天前
已完结
Helicogenic Amino Acid Increases Passive Permeability and Oral Bioavailability of Macrocycles by Preorganizing γ-Turn
21天前
已完结
Coibamide Analogue as a Novel-Class Payload for Antibody-Drug Conjugate
1个月前
已完结
Discovery of novel and selective SIK2 inhibitors by the application of AlphaFold structures and generative models
1个月前
已完结
Discovery of novel KSP-targeting PROTACs with potent antitumor effects in vitro and in vivo
1个月前
已完结
Understanding the activation mechanism of GLP-1R/GIPR by dual agonist Tirzepatide via molecular dynamics and protein-peptide binding
1个月前
已完结
IL-17A functions and the therapeutic use of IL-17A and IL-17RA targeted antibodies for cancer treatment
1个月前
已完结
Thiazole‐based IL‐17 inhibitors discovered by scaffold morphing
1个月前
已完结
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