Lv6
2598 积分 2025-08-07 加入
Discovery of Potent Multikinase Type-II Inhibitors Targeting CDK5 in the DFG-out Inactive State with Promising Potential against Glioblastoma
7小时前
待确认
Structure-Based Design of Potent Selective Nanomolar Type-II Inhibitors of Glycogen Synthase Kinase-3β
8小时前
待确认
Cancer burden in the HIV-infected population in the United States
9小时前
待确认
Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors
1天前
待确认
Conformational Analysis of the DFG-Out Kinase Motif and Biochemical Profiling of Structurally Validated Type II Inhibitors
2天前
已完结
Exploring the kinase-inhibitor fragment interaction space facilitates the discovery of kinase inhibitor overcoming resistance by mutations
2天前
已完结
A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases
2天前
已完结
Exploiting structural variability in the kinase back-pocket to modulate polypharmacology of TAM inhibitors
2天前
已完结
DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity
2天前
已完结
Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation
2天前
已完结
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