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26 积分 2026-01-28 加入
Discovery and Structural Optimization of Elephantopus scaber -Derived Sesquiterpene Lactones as Covalent PRDX6 Inhibitors for Colorectal Cancer
2小时前
待确认
Discovery of Novel Sesquiterpene Lactone Derivatives as Potent PKM2 Activators for the Treatment of Ulcerative Colitis
9天前
已完结
From Structure to Selectivity: Integrating CADD and AIDD in Rational Medicinal Chemistry Strategies for DYRK1A Inhibitor Discovery
20天前
已完结
A Structural Perspective on Non-covalent Targeting of Conserved Polar Residues in Protein Kinases
1个月前
已完结
Structure-Based Discovery of HS34: A Highly Selective and Orally Bioavailable CDK9 Inhibitor for Triple-Negative Breast Cancer
1个月前
已完结
Rational Design of Oxazolonylflavone Derivatives as Novel CDK4/9 Inhibitors with Potent Antitumor Efficacy and Oral Bioavailability
1个月前
已完结
Practical Crystallization Strategies for Medicinal Chemists
1个月前
已完结
Amino Acid Modified Xanthone Derivatives: Novel, Highly Promising Membrane-Active Antimicrobials for Multidrug-Resistant Gram-Positive Bacterial Infections
9个月前
已完结
Discovery of novel dihydropyrrolidone-thiadiazole compound crosstalk between the YycG/F two-component regulatory pathway and cell membrane homeostasis to combat methicillin-resistant Staphylococcus aureus
9个月前
已完结
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