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35 积分 2025-06-25 加入
Plumbagin inhibits CYP2J/EETs metabolic pathway and leads to heart injury in cardiac organoids and rats
9天前
已完结
Organoids and Organoids-on-Chip in Traditional Chinese Medicine Research: Applications, Advantages, and Future Prospects
9天前
已完结
Guanxinning injection ameliorates cardiac remodeling in HF mouse and 3D heart spheroid models via p38/FOS/MMP1-mediated inhibition of myocardial hypertrophy and fibrosis
9天前
已完结
Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues
14天前
已完结
From cells to systems: A comprehensive perspective on In-Vitro, In-Vivo, and 3D culture models of heart failure
14天前
已完结
From cells to systems: A comprehensive perspective on In-Vitro, In-Vivo, and 3D culture models of heart failure
14天前
已关闭
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
14天前
已完结
Cardiac organoids seeded with tissue-resident macrophages model arrhythmia
15天前
已完结
各模型均以人源心肌细胞为基础，在3D组织环境中复现了折返、传导阻滞、电-代谢耦联脱节等临床心律失常核心表型，并通过多模态实时监测与药物干预验证了其用于机制研究和抗心律失常药物筛选的可行性。 共同不足： 各模型普遍存在心肌成熟度有限、缺乏神经-免疫-血管微环境、细胞组成不完整及通量偏低等局限，目前多聚焦于单一病因或心律失常类型，尚未广泛拓展至患者特异性及复杂共病环境下的个体化建模。
16天前
已完结
Electro-metabolic coupling in multi-chambered vascularized human cardiac organoids
16天前
已完结
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