Lv64
1800 积分 2023-10-27 加入
Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat
2小时前
已完结
Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers
2小时前
已完结
Resmetirom, the first approved drug for the management of metabolic dysfunction-associated steatohepatitis: Trials, opportunities, and challenges
1个月前
已完结
First US drug approved for a liver disease surging around the world
1个月前
已完结
Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy
2个月前
已完结
Stepwise activation of SARM1 for cell death and axon degeneration revealed by a biosynthetic NMN mimic
2个月前
已完结
Development and Comprehensive Benchmark of a High-Quality AMBER-Consistent Small Molecule Force Field with Broad Chemical Space Coverage for Molecular Modeling and Free Energy Calculation
2个月前
已完结
Optimization of Brain Penetrant SARM1 Orthosteric Inhibitors and Discovery of Their Paradoxical Subinhibitory Activation
2个月前
已完结
Holistic Prediction of pKa in Diverse Solvents Based on Machine Learning Approach
2个月前
已完结
The IUPAC aqueous and non-aqueous experimental pKa data repositories of organic acids and bases
2个月前
已完结
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