Lv31
240 积分 2023-06-17 加入
Small molecule interleukin (IL) 17A/A antagonists and antibodies blocking both IL17A/A and IL17A/F demonstrate equivalent degrees of efficacy in preclinical models of skin and joint inflammation
6天前
已完结
Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds
6天前
已完结
Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein–Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases
6天前
已完结
Discovery and In Vivo Exploration of 1,3,4-Oxadiazole and α-Fluoroacrylate Containing IL-17 Inhibitors
6天前
已完结
Harnessing Glutamine-117 Plasticity toward Structure-Based Identification of Triazole IL-17 Inhibitors
8天前
已完结
Antibody-Drug Conjugates with Pyrrole-Based KSP Inhibitors as the Payload Class
13天前
已完结
Impact of Payload Hydrophobicity on the Stability of Antibody–Drug Conjugates
19天前
已完结
Evaluating datopotamab deruxtecan (Dato-DXd) as a novel treatment option for EGFR-mutated non-small cell lung cancer
19天前
已完结
Site-specific conjugation of native antibodies using engineered microbial transglutaminases
22天前
已完结
Artificial intelligence in drug development
25天前
已完结
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