Lv51
1184 积分 2024-03-19 加入
Discovery of Pyrazole-based Selective Covalent ITK Inhibitors with In Vivo Activity
1小时前
求助中
Structure-Activity Relationships in a Series of Dihydrouracil-JQ1 Conjugates: Discovery of Highly Potent BRD4 Degraders
17天前
已完结
Discovery of MK-5661, a Once-Daily Oral Na V 1.8 Inhibitor for the Treatment of Pain
28天前
已完结
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS
1个月前
已完结
Discovery of Potent 1,3-Cyclobutane-Containing Dual A 2A /A 2B Receptor Antagonists with Low Projected Human Dose for the Treatment of Cancer
1个月前
已完结
Targeting the H/KRAS α4-β6-α5 Allosteric Lobe with Macrocyclic Peptides
1个月前
已完结
Lessons from Structural Biology for Understanding Drug Resistance in Gastrointestinal Stromal Tumors (GIST)
1个月前
已完结
Optimization of α-Fluoro, β-Heteroaryl Acrylamide Warheads for KRAS G12C Active-State Inhibition
1个月前
已完结
Targeting WRN helicase in MSI-H tumors: Synthetic lethality, small molecule discovery, and therapeutic perspectives
1个月前
已关闭
Evaluation of Oral PROTAC Guidelines: Efflux Ratio Outweighs Chameleonicity Descriptors
1个月前
已完结
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