Lv52
1384 积分 2024-12-10 加入
Novel selective agents for the degradation of AR/AR-V7 to treat advanced prostate cancer
2小时前
已完结
Molecular glue degraders: Rational design, specificity engineering, and advanced delivery
7天前
已完结
Development of APH003─a Highly Potent, Selective, and Orally Bioavailable IRAK4 PROTAC Degrader for the Treatment of Inflammatory Diseases
19天前
已完结
New PROTAC Designs for Targeted Protein Degradation in 2021–2025: Novel E3 Ligases and Pre-PROTACs
1个月前
已完结
Developing potent anti-inflammatory IRAK4-targeting PROTACs with simplified CRBN ligands
2个月前
已完结
Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors
2个月前
已完结
A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors
2个月前
已完结
Discovery of LC-MI-3: A Potent and Orally Bioavailable Degrader of Interleukin-1 Receptor-Associated Kinase 4 for the Treatment of Inflammatory Diseases
2个月前
已完结
The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-N-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke
2个月前
已完结
Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation
2个月前
已完结
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