Lv41
469 积分 2021-08-29 加入
Discovery of potent and selective HER2 PROTAC degrader based Tucatinib with improved efficacy against HER2 positive cancers
43分钟前
待确认
Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
4天前
已完结
Small-molecule-induced polymerization triggers degradation of BCL6
13天前
已完结
Discovery of CBPD-409 as a Highly Potent, Selective, and Orally Efficacious CBP/p300 PROTAC Degrader for the Treatment of Advanced Prostate Cancer
18天前
已完结
Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections
20天前
已完结
Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models
20天前
已完结
Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia
20天前
已完结
Discovery of CECR2 Bromodomain Inhibitors with High Selectivities over BPTF Bromodomain
21天前
已完结
Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites
29天前
已完结
In Vitro ADME Profiling of PROTACs: Successes, Challenges, and Lessons Learned from Analysis of Clinical PROTACs from a Diverse Physicochemical Space
1个月前
已完结
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