Lv41
446 积分 2021-04-15 加入
Discovery of Edecesertib (GS-5718): A Potent, Selective Inhibitor of IRAK4
4小时前
已完结
Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton’s Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies
4小时前
已完结
Palladium‐Catalyzed Asymmetric Reductive Heck Reaction of Aryl Halides
5天前
已完结
Evidence for Dearomatizing Spirocyclization and Dynamic Effects in the Quasi-stereospecific Nitrogen Deletion of Tetrahydroisoquinolines
5天前
已完结
Identifying Potent Compounds Using Pairwise Consensus Methods
17天前
已完结
Discovery of (S)-1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain
27天前
已完结
Discovery of a Potent (4R,5S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling
1个月前
已完结
A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists
1个月前
已完结
Advances in TRP channel drug discovery: from target validation to clinical studies
1个月前
已完结
Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity
1个月前
已完结
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