Lv717
3378 积分 2024-09-24 加入
Molecular hybridization strategy - discovery of 2,3-diarylpyrazine derivatives as potent Skp2 inhibitors with improved anti-tumor activity and enhanced cisplatin sensitivity
7天前
已完结
AZD5438-PROTAC: A selective CDK2 degrader that protects against cisplatin- and noise-induced hearing loss
8天前
已完结
Novel technetium-99m-labelled ribociclib isocyanide derivatives for imaging cyclin-dependent kinase 4/6 (CDK4/6) expression in cancer
8天前
已完结
Design, synthesis, and biological evaluation of novel 4,4′-bipyridine derivatives acting as CDK9-Cyclin T1 protein-protein interaction inhibitors against triple-negative breast cancer
8天前
已完结
Scaffold hopping of celastrol provides derivatives containing pepper ring, pyrazine and oxazole substructures as potent autophagy inducers against breast cancer cell line MCF-7
8天前
已完结
Design, Synthesis, and Antiproliferative Efficacy of an Innovative Series of Triazino[5,6-b]indole Derivatives Targeting EGFR, CD1, Hsp90, PI3K, and ERK/AKT as Key Molecular Targets in Cancer Therapy
8天前
已完结
Rationally designed Pyrazolo[1,5-a]pyrimidines as dual inhibitors of CA IX/XII and CDK6: A novel approach for NSCLC treatment
8天前
已完结
Development of fluorizoline analogues as prohibitin ligands that modulate C-RAF signaling, p21 expression and melanogenesis
8天前
已完结
Discovery of potent and selective CDK2 inhibitors with high safety and favorable bioavailability for the treatment of cancer
8天前
已完结
Discovery and optimization of novel tetrahydrothiazolopyridine-based pyrimidines as highly potent cyclin-dependent kinase 9 (CDK9) inhibitors
8天前
已完结
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