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已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!
李RP
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[22] Li M, Dong Y, Yu X, Li Y, Zou Y, Zheng Y, He Z, Liu Z, Quan J, Bu X, Wu H. Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer's Disease. J Med Chem. 2017 Aug 10;60(15):6664-6677
9小时前
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[21] Van Manh N, Hoang VH, Ngo VTH, Kang S, Jeong JJ, Ha HJ, Kim H, Kim YH, Ann J, Lee J. Discovery of potent indazole-based human glutaminyl cyclase (QC) inhibitors as Anti-Alzheimer's disease agents. Eur J Med Chem. 2022 Dec 15;244:114837
9小时前
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[20] Hoang VH, Tran PT, Cui M, Ngo VT, Ann J, Park J, Lee J, Choi K, Cho H, Kim H, Ha HJ, Hong HS, Choi S, Kim YH, Lee J. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design. J Med Chem. 2017 Mar 23;60(6):2573-2590
9小时前
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[19] POZZI C, DI PISA F, BENVENUTI M, et al. The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders [J]. Journal of Biological Inorganic Chemistry, 2018, 23(8): 1219-1226
9小时前
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[18] Huang KF, Wang YR, Chang EC, Chou TL, Wang AH. A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis. Biochem J. 2008 Apr 1;411(1):181-90
9小时前
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[17] Valenti M T, Bolognin S, Zanatta C, et al. Increased Glutaminyl Cyclase Expression in Peripheral Blood of Alzheimer's Disease Patients[J]. Journal of Alzheimer’s Disease, 2013,34:263-271
9小时前
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[16] LI M, DONG Y, YU X, et al. Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer's Disease [J]. Journal of Medicinal Chemistry, 2017, 60(15): 6664-6677
9小时前
求助中
[15] BUCHHOLZ M, HEISER U, SCHILLING S, et al. The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship [J]. Journal of Medicinal Chemistry, 2006, 49(2): 664677
9小时前
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[14] Schilling S, Hoffmann T, Rosche F, Manhart S, Wasternack C, Demuth HU. Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity. Biochemistry. 2002 Sep 3;41(35):10849-57
9小时前
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[13] Castaldo C, Ciambellotti S, de Pablo-Latorre R, Lalli D, Porcari V, Turano P. Soluble variants of human recombinant glutaminyl cyclase. PLoS One. 2013 Aug 15;8(8):e71657
9小时前
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