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3200 积分 2023-09-04 加入
In Vitro ADME Profiling of PROTACs: Successes, Challenges, and Lessons Learned from Analysis of Clinical PROTACs from a Diverse Physicochemical Space
2天前
已完结
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders
2天前
已完结
Development of a Buchwald–Hartwig Amination for an Accelerated Library Synthesis of Cereblon Binders
3天前
已完结
Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy
3天前
已完结
Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation
1个月前
已完结
An Integrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACs
1个月前
已完结
Impact of Linker Composition on VHL PROTAC Cell Permeability
1个月前
已完结
Factors to Consider for Synthesis in 1536-Well Plates─An Amide Coupling Case Study for PROTAC Synthesis
1个月前
已完结
Structural and Physicochemical Features of Oral PROTACs
1个月前
已完结
Impact of Linker Composition on VHL PROTAC Cell Permeability
1个月前
已完结
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