Lv51
890 积分 2025-02-12 加入
Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering
8小时前
已完结
Novel N-Methylated Cyclodepsipeptide Prodrugs for Targeted Cancer Therapy
4天前
已完结
Development of a 177Lu-labeled EphA2-targeting cyclic peptide combined with an HPK1 inhibitor for synergistic anti-tumor effects
1个月前
已完结
Discovery of Potent and Selective Pyrrolo[2,3-d]pyrimidine Derivatives as Fourth-Generation EGFR Inhibitors Targeting Triple Mutations
1个月前
已完结
Fragment-Based Discovery and Structure-Led Optimization of MSC778, the First Potent, Selective, and Orally Bioavailable FEN1 Inhibitor
1个月前
已完结
Discovery of Potent and Selective Reversible Ubiquitin-Like Modifier Activating Enzyme 5 Inhibitors Targeting the UFMylation Pathway
1个月前
已完结
Beyond Bioisosteres: Impact of Replacing a Benzene Ring with sp3-Rich Three-Dimensional Saturated Bridged Bicyclic Match Pairs on Biotransformation, Metabolic Stability, and Other ADME Profiles
1个月前
已完结
Direct Deaminative Halogenation at Hindered Tertiary Centers
1个月前
已完结
Unlocking the power of affibody conjugated radioactive metallopharmaceuticals for targeted cancer diagnosis and therapy
1个月前
已完结
Trithiol ligand provides tumor-targeting 191Pt-complexes with high molar activity and promising in vivo properties
2个月前
已完结
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