Lv629
2370 积分 2024-06-28 加入
The Role of Fluorine in the Discovery and Optimization of CNS Agents: Modulation of Drug-Like Properties
5天前
已关闭
Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept
11天前
已完结
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions
12天前
已完结
Discovery of 1-Difluoromethyl-3-(3-cyanophenyl)-6-[4-(trifluoromethoxy)phenyl]imidazo[1,5-a]pyrazin-8-(7H)-one as a Potent P2Y1 Antagonist for the Treatment of Ischemic Stroke and Myocardial Infarction
12天前
已完结
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα
12天前
已完结
AI-Driven Discovery and Optimization of Positive Allosteric Modulators for NMDA Receptors: Potential Applications in Depression
19天前
已完结
Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits
19天前
已完结
The Application of Deuteration Strategy in Drug Design
27天前
已完结
A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons
1个月前
已完结
Synthesis and antidepressant effect of novel aralkyl piperazine and piperidine derivatives targeting SSRI/5-HT1A/5-HT7
1个月前
已完结
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