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The Disconnect in Intrinsic Clearance Determined in Human Hepatocytes and Liver Microsomes Results from Divergent Cytochrome P450 Activities
1个月前
已完结
Integrated cytochrome P450 reaction phenotyping: attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes
4个月前
已完结
Discussion
4个月前
已关闭
Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping
7个月前
已完结
VALIDATED ASSAYS FOR HUMAN CYTOCHROME P450 ACTIVITIES
7个月前
已完结
Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and induction), and clinical significance
7个月前
已完结
Application of transporter assays for drug discovery and development: an update of the literature
7个月前
已完结
In Vivo/In vitro metabolic profiling and evaluation of key metabolites of QO-83, a novel KCNQ channel opener with antiepileptic potential
8个月前
已完结
The importance of plasma protein and tissue binding in a drug discovery program to successfully deliver a preclinical candidate
9个月前
已完结
Insights on the in-vitro binding characteristics of human α-1-acid glycoprotein (HAG) with JAK inhibitor ocalcitinib: Multi-spectroscopic analysis combined with theoretical calculations
10个月前
已完结
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