Lv11
20 积分 2025-02-11 加入
Discovery of Potent and Orally Effective Dual Janus Kinase 2/FLT3 Inhibitors for the Treatment of Acute Myelogenous Leukemia and Myeloproliferative Neoplasms
1小时前
待确认
Discovery of Highly Selective and Potent Macrocyclic JAK2 Inhibitors for the Treatment of MPNs
5小时前
已完结
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3
24天前
已完结
Closing the Design–Make–Test–Analyze Loop: Interplay between Experiments and Predictions Drives PROTACs Bioavailability
1个月前
已完结
Intercepting the Downstream of the Estrogen Receptor Signaling Pathway: Discovery of a Potent and Efficient SRC-3 PROTAC Degrader for Overcoming Endocrine Resistance Breast Cancer
2个月前
已完结
Discovery of an Orally Bioavailable and Brain Penetrant Selective Estrogen Receptor Degrader
3个月前
已完结
Discovery and Characterization of PVTX-321 as a Potent and Orally Bioavailable Estrogen Receptor Degrader for ER+/HER2– Breast Cancer
3个月前
已完结
Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts
3个月前
已完结
Rational Design of Methylene Blue–Raloxifene Conjugates for Efficient Breast Tumor Elimination Triggered by ERα Degradation
3个月前
已完结
Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras
3个月前
已完结
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