Lv1
26 积分 2025-02-11 加入
Investigation of binding mechanism and downregulation of elacestrant for wild and L536S mutant estrogen receptor‐α through molecular dynamics simulation and binding free energy analysis
2小时前
待确认
Discovery of ZN-c5, an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) with Improved Pharmacokinetics
2小时前
已完结
Overcoming E3 Ligase-Mediated Resistance: Development of Novel Hydrophobic Tagging-Based Degraders Targeting ALK Protein
10天前
已完结
Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice
10天前
已完结
A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice
10天前
已完结
Peptidomimetic inhibitors of APC–Asef interaction block colorectal cancer migration
11天前
已完结
Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor
12天前
已完结
De Novo Discovery of a Macrocyclic Peptide Antagonist of Interleukin-11 with Antirenal Fibrotic Efficacy
12天前
已完结
De Novo Discovery of a Macrocyclic Peptide Antagonist of Interleukin-11 with Antirenal Fibrotic Efficacy
17天前
已完结
Developing New Strategies to Construct Pseudo-natural Macrocycles for Undruggable Targets
25天前
已完结
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