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28 积分 2024-08-24 加入
Discovery of Novel Potent and Safe Immunoproteasome Inhibitors with Bridged Ring for Anti-Inflammatory Therapy
5天前
已完结
Astragalin Inhibits Oxidative Stress‐Induced Pyroptosis and Apoptosis in Mouse Models of Renal Ischemia/Reperfusion Injury by Activating the SIRT1 /Nrf2 Pathway
4个月前
已完结
Magnesium Lithospermate B Protects Against Ischemic AKI-to-CKD progression via regulating the KLF5/CDK1/Cyclin B1 pathway
4个月前
已完结
NR4A1 silencing alleviates high-glucose-stimulated HK-2 cells pyroptosis and fibrosis via hindering NLRP3 activation and PI3K/AKT pathway
4个月前
已完结
Abstract LB-054: Discovery and profiling of M3258, a potent and selective LMP7 inhibitor demonstrating high efficacy in multiple myeloma models
5个月前
已关闭
Low-Grade Chronic Inflammation: a Shared Mechanism for Chronic Diseases
5个月前
已完结
Alchemical Transformations and Beyond: Recent Advances and Real-World Applications of Free Energy Calculations in Drug Discovery
5个月前
已完结
Deep Lead Optimization: Leveraging Generative AI for Structural Modification
5个月前
已完结
Non-peptidic immunoproteasome β5i-selective inhibitor as potential treatment for idiopathic pulmonary fibrosis: Virtual screening, hit evolution and lead identification
5个月前
已完结
Immunoproteasome inhibition triggers protein stress and apoptosis in cells of B cell lineage without impairing vaccination-induced antibody responses
6个月前
已完结
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