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58 积分 2025-03-14 加入
Development of APH003─a Highly Potent, Selective, and Orally Bioavailable IRAK4 PROTAC Degrader for the Treatment of Inflammatory Diseases
19天前
已完结
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells
1个月前
已完结
Advances and challenges in kidney fibrosis therapeutics
3个月前
已完结
Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease
3个月前
已完结
A dual αvβ1/αvβ6 integrin inhibitor Bexotegrast (PLN-74809) ameliorates organ injury and fibrogenesis in fibrotic kidney disease
4个月前
已完结
Establishment of an orthotopic glioblastoma mouse model for preclinical studies
4个月前
已完结
Developing potent anti-inflammatory IRAK4-targeting PROTACs with simplified CRBN ligands
4个月前
已完结
Discovery and characterization of SIM0711, a potent and selective IRAK4 PROTAC with enhanced efficacy and safety 4626
4个月前
已完结
Design, Synthesis, and Evaluation of Nucleolin-Bridged, MDM2-Recruiting IRAK4 Degraders for the Treatment of Autoimmune Diseases
4个月前
已完结
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