Lv22
110 积分 2026-02-28 加入
Structure-Guided Discovery of Potent, Selective, and Orally Bioavailable Werner Syndrome RecQ Helicase Inhibitors for the Treatment of Microsatellite Instability-High Tumors
1小时前
待确认
SHP2 Inhibition Reveals Compensatory PI3K-AKT Activation in KRAS-Driven Pancreatic Cancer: Discovery of SDUY104 and Rational Approaches for Combination Therapy
1天前
已完结
PROTAC-Mediated DPP-4 Degradation: A New Solution for Type 2 Diabetes
1天前
已完结
Enzyme-Triggered Charge and Conformation Switching for Tumor-Selective Peptide–Drug Conjugates
20天前
已完结
Discovery and Optimization of 4-Methylquinazoline Derivatives as Highly Selective PI3Kδ Inhibitors for the Treatment of Acute Lung Injury
21天前
已完结
A Click Chemistry Approach for Developing Organelle-Directed Photocytotoxic Ruthenium(II) Probes
1个月前
已完结
New Reversible Covalent Warheads: Cyanobenzothiazoles Recruiting DCAF16 for Targeted Protein Degradation
1个月前
已完结
Tumor Microenvironment-Responsive Antibody Fragment-Cleavable PEGylated Drug Conjugates (AFCDC) for Improved Tumor Penetration and Antitumor Efficacy
1个月前
已完结
Nucleoside-ATTEC Conjugates for Targeting Inhibition of HIV Replication and Infection
2个月前
已完结
Discovery and Evaluation of a PROTAC Degrader Targeting SAMHD1 for the Treatment of Pulmonary Fibrosis
2个月前
已完结
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