Lv5
1050 积分 2024-01-05 加入
MAT2A inhibition combats metabolic and transcriptional reprogramming in cancer
23天前
已完结
S-adenosylmethionine addiction confers sensitivity to methionine restriction in <i>KMT2A</i>-rearranged acute lymphoblastic leukemia
1个月前
已完结
Discovery of novel MAT2A inhibitors by an allosteric site-compatible fragment growing approach
1个月前
已完结
Discovery of Potential Scaffolds for Methionine Adenosyltransferase 2A (MAT2A) Inhibitors: Virtual Screening, Synthesis, and Biological Evaluation
1个月前
已完结
Design and Structural Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High In Vivo Potency and Oral Bioavailability
2个月前
已完结
Discovery of Novel Spirocyclic MAT2A Inhibitors Demonstrating High In Vivo Efficacy in MTAP-Null Xenograft Models
2个月前
已完结
Computer-aided design of a fluorescent MAT2A inhibitor for visualized cancer synthetic lethality
2个月前
已完结
Targeting the methionine−methionine adenosyl transferase 2A−S-adenosyl methionine axis for cancer therapy
2个月前
已完结
Combined inhibition by PRMT5 and MAT2A demonstrates a strong synthetic lethality in MTAP homozygous-deficient glioma models
2个月前
已完结
Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy
2个月前
已完结
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